Unlocking key insights into gene expression using a novel mouse model

A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as ...
EurekAlert!

One-step creation of Cre-loxP organisms: precise control and modification of gene expression

Mice and newts were applied to the one-step Cre-loxP organism creation technology by TAx9. In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short DNA ...
Science Daily

A novel switch to turn genes on/off on cue, a promising step toward safer gene therapy

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to ...
BioTechniques

Quality control and analysis of gene expression experiments

Gene expression analysis using qPCR quantification of RNA transcripts expressed by cells or viruses plays an important role in the discovery and development of novel biotherapeutics. While widely used ...
Baylor College of Medicine

A novel switch to turn genes on/off, promising step toward safer gene therapy

Just like a doctor adjusts the dose of a medication to the patient’s needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to ...
Phys.org

Novel switch turns genes on/off on cue, a promising step toward safer gene therapy

A synthetic PAS (red) is inserted in the 5′ UTR of a transgene. Without ligand, the cleavage destroys the coding region of the mRNA, therefore, losing transgene expression. Ligand binding to the ...