New research has uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, two dimeric ...

Immunome Inc. IMNM said the U.S. Food and Drug Administration (FDA) has accepted its New Drug Application for varegacestat, an investigational oral, once-daily gamma secretase inhibitor, for the ...

June 15, 2007 (Washington, DC) — A drug that deactivates gamma-secretase, an enzyme involved in amyloid-beta (Abeta) synthesis, appears to be safe and reduces plasma concentrations of Abeta in ...

A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's ...

From the Damian Green Lab, in collaboration with the Geoff Hill and Riddell Labs, Translational Sciences and Therapeutics Division and David Coffey, Division of Myeloma, at the University of Miami To ...

A first-in-human, phase I study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors. Background: Aberrant Notch signaling is ...

Scientists at the Massachusetts General Hospital (MGH) have developed a molecular imaging probe to reveal Alzheimer's disease (AD)-related γ-secretase in rodents and macaques with translational ...

A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with ...

Based on structural similarities with other targets of the gamma-secretase system, researchers from Columbia University Irving Medical Center in the United States show that the SARS-CoV-2 receptor for ...

Phase I trial of anti-PSMA designer T cells in advanced prostate cancer. Background: Gamma-secretase inhibitors (GSIs), which block activation of the oncogenic protein Notch homolog-1 (NOTCH-1) are ...