Germline genetic screening can identify whether a patient with cancer has inherited genetic alterations in a gene or genes ...

However, applying a conventional age-based testing threshold would have substantially reduced the number of patients identified. Restricting testing to patients diagnosed before age 50 would have ...

Background: There is limited research examining demographic, disease-related, and social factors that may influence veterans’ participation in germline genetic testing. This study sought to identify ...

A study of nearly 40,000 cancer patients found that age-based germline genetic testing policies would miss about 72 percent of carriers of inherited pathogenic variants, supporting universal testing ...

From 7% to nearly 9% of patients with advanced cancer were found to harbor a germline variant with targeted therapeutic actionability in the first study of its kind. The study involved 11,974 patients ...

Please provide your email address to receive an email when new articles are posted on . Most patients with cancer who have genetic variants linked to their disease view it as their responsibility to ...

Comprehensive somatic CGP at diagnosis enables identification of actionable alterations, therapeutic targets, resistance mutations, and clinical trial eligibility, tightening alignment between tumor ...

A retrospective cohort of 259 Colombian breast cancer patients with germline pathogenic variants found a ten-year overall ...

Please provide your email address to receive an email when new articles are posted on . Nearly all individuals who self-navigated the entire online platform completed germline testing. The platform ...

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The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I ...

Universal germline genetic testing of nearly 40,000 patients with solid tumors detected a substantial proportion of inherited gene ...