Lupus Science & Medicine

Integrated immune profiling identifies a coordinated T-cell activation and inflammatory signature in SLE

Introduction Patients with SLE have an increased risk of infections and infection-related mortality, which may be associated ...
Lupus Science & Medicine

International development of a lupus-specific instrument to assess cognitive symptoms in patients with SLE: Lupus Brain Fog Severity Scale (LBFSS) study

Introduction Cognitive symptoms such as ‘brain fog’ are frequent and disabling in patients with SLE. We aimed to develop and ...
Lupus Science & Medicine

Upadacitinib enhances platelet procoagulant responses in a subset of healthy individuals and patients with SLE: a pilot study

Background Janus kinase inhibitors (JAKis) are emerging therapies for SLE, but concerns regarding thromboembolic risk persist ...
Lupus Science & Medicine

Qualitative interview study in patients with SLE to assess patient perception of fatigue and skin-related symptoms

Objective SLE is a chronic autoimmune disorder with a range of symptoms. While these are broadly reported in the literature, ...
lupus.bmj

PS7:135 Amg 592 is an investigational il-2 mutein that induces highly selective expansion of regulatory t cells

Background AMG 592 is an investigational IL-2 mutein designed for greater regulatory T-cell (Treg) selectivity and longer half-life than recombinant IL-2 (aldesleukin). We investigated the ...
lupus.bmj

Effects of systemic lupus erythematosus on the brain: a systematic review of structural MRI findings and their relationships with cognitive dysfunction

Background Cognitive dysfunction (CD) is highly prevalent in systemic lupus erythematosus (SLE), yet the underlying mechanisms are poorly understood. Neuroimaging utilising advanced MRI metrics may ...
lupus.bmj

Associations of metabolic syndrome in SLE

Objectives To characterise the prevalence and associations of metabolic syndrome (MetS) in a multiethnic cohort of patients with SLE. Methods Using a standardised protocol, baseline demographics, per ...
lupus.bmj

Immune complex–driven neutrophil activation and BAFF release: a link to B cell responses in SLE

Objective The role of neutrophils in driving pathogenic B cell responses in SLE is not fully understood. In this study, we explored the link between immune complex (IC)–driven neutrophil activation, ...
lupus.bmj

Current Issue

Original research: Development and validation of a lectin-based assay for detection of IgG Fc glycosylation as a biomarker in lupus nephritis (2 July, 2026) ...
lupus.bmj

Amelioration of renal injury by Qihuang Jianpi Zishen Granules in lupus mice is correlated with AMPK/ULK1-dependent modulation of macrophage polarisation

Objective To investigate the effects of Qihuang Jianpi Zishen Granules (QJZG) on renal injury in SLE mice, focusing on macrophage M1/M2 polarisation mediated by the AMPK/ULK1 signalling pathway.
lupus.bmj

PT2:02 Plasma metabolomic profiling reveals serine-centered immunometabolic modulation by SGLT2 inhibition in lupus nephritis

Objectives Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), leading to chronic kidney damage and increased mortality. Metabolomic studies have ...
lupus.bmj

Metabolomic analysis suggests thiamine monophosphate as a potential marker for mesenchymal stem cell transplantation outcomes in patients with SLE

Objective The objective of this research is to identify metabolic markers associated with successful treatment by evaluating the effect of mesenchymal stem cell transplantation (MSCT) on the metabolic ...